She was born in 1941 in Buenos Aires, Argentina. She studied at the Manuel Belgrano National School of Fine Arts. In 1958 she traveled to Mexico, where she studied engraving at the Universidad Iberoamericana. In 1964 she settled in New York and attended the Pratt Graphic Art Center. Together with Luis Camnitzer and José Guillermo Castillo she founded the New York Graphic Workshop and formulated, in 1967, the concept of FANDSO (free assemblage, non-functional, disposable, serial object). In 1971 she participated in the creation of the Imaginary Latin American Museum, a museum without walls, in contrast to the Center for Inter-American Relations (CIR) and its regressive policy. In 1977 she co-founded and taught printmaking at Studio Camnitzer-Porter in Lucca, Italy. From 1991 to 2007 she was a professor in the Department of Art at the City University of New York, CUNY, Queens College. Among other distinctions she received the Guggenheim scholarship in 1980. She is a Corresponding Academic of the National Academy of Fine Arts (Argentina) and Corresponding Academic of Argentina for the United States.

Her work is represented in numerous public and private collections, including: the Metropolitan Museum, the Museum of Modern Art, the Whitney Museum of American Art and the New York Public Library, the Museum of Latin American Art of Buenos Aires ( Malba), the Museum of Modern Art and the Museum of Fine Arts of Buenos Aires; the Daros Foundation in Switzerland, the Tate Modern in London, the Patricia P. de Cisneros Collection, the National Library of Paris; the Reina Sofía Museum of Spain; and the Tamayo Museum of Mexico. She lives and works in New York.