Marcelo Alzetta was born in Tandil, Buenos Aires province, on September 19th, 1977. He had a fragile childhood due to situs inversus, a rare genetic malformation. Since he was little he liked to paint and he did it with the conviction of someone who wants to be an artist. As a teenager he began to attend the classes of the Uruguayan cartoonist Alberto Breccia, in his workshop he met the group with which he was going to found El Tripero collective and create the mythical magazine with the same name. He took classes with Ahuva Szlimowicz and met Pablo Suárez who linked him to some artists from the nineties scene, with whom he began to participate in collective exhibitions at the end of the decade. He moved to Buenos Aires where he lived for a few years, but in 2007 he had to return to Tandil due to complications related to his illness; two years later he had a lung transplant. Despite the distance, his link with the scene in the capital continued to be active, in 2008 he had his first solo exhibition, Windows 77: Fantasy, at the LDF gallery and throughout the following decade he exhibited frequently both collectively and individually.

In 2017 Ivan Rosado edited the book Paseo with his drawings and paintings. In 2019 Francisco Garamona directed the documentary Marcelo Alzetta: Una baldosa renacentista that collects the testimony of the artist from his apartment in Tandil. The following year Metamúsica released Museo Primitivo his first long-playing album where he captured another of the facets that he developed throughout his career, electronic music. The last few years were critical, he lived connected to an oxygen tube and his health deteriorated more and more. At age 43, he died on May 2, 2021 while waiting for a second transplant that never came.